|
KMID : 0338420190340051068
|
|
Korean Journal of Internal Medicine
2019 Volume.34 No. 5 p.1068 ~ p.1077
|
|
|
Higher glucagon-to-insulin ratio is associated with elevated glycated hemoglobin levels in type 2 diabetes patients
|
|
Lee Min-Young
Kim Min-Kyung
Park Jong-Suk
Lee Sang-Bae
You Ji-Hong
Ahn Chul-Woo
Kim Kyung-Rae
Kang Shin-Ae
|
|
|
Abstract
|
|
|
Background/Aims: The importance of α-cell dysfunction in the pathogenesis of type 2 diabetes has re-emerged recently. However, data on whether relative glucagon excess is present in clinical settings are scarce. We aimed to investigate associations between glucagon-to-insulin ratio and various metabolic parameters.
Methods: A total of 451 patients with type 2 diabetes naive to insulin treatment were recruited. Using glucagon-to-insulin ratio, we divided subjects into quartiles according to both fasting and postprandial glucagon-to-insulin ratios.
Results: The mean age of the subjects was 58 years, with a mean body mass index of 25 kg/m2 The patients in the highest quartile of glucagon-to-insulin ratio had higher glycated hemoglobin (HbA1c) levels. HbA1c levels were positively correlated with both fasting and postprandial glucagon-to-insulin ratios. Subjects in the highest quartile of postprandial glucagon-to-insulin ratio were more likely to exhibit uncontrolled hyperglycemia, even after adjusting for confounding factors (odds ratio, 2.730; 95% confidence interval, 1.236 to 6.028; p for trend < 0.01).
Conclusions: Hyperglucagonemia relative to insulin could contribute to uncontrolled hyperglycemia in type 2 diabetes patients.
|
|
|
KEYWORD
|
|
|
Glucagon, Insulin, Hemoglobin A, glycosylated, Diabetes mellitus, type 2, Hyperglycemia
|
|
|
FullTexts / Linksout information
|
|
 
|
|
|
Listed journal information
|
|
    
|